Oxidation of Enrofloxacin with Permanganate: Kinetics, Multivariate Effects, Identification of Oxidation Products, and Determination of Residual Antibacterial Activity
المؤلفون المشاركون
Cui, Fuyi
Xu, Yongpeng
Liu, Shiyao
Guo, Fang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Permanganate [Mn(VII)] chemistry oxidation of fluoroquinolone (FQ) antibiotic enrofloxacin (ENR) in water is investigated with respect to the kinetics, pH effect, buffer effect, and the evaluation of residual antibacterial activity after oxidative treatment.
The degradation of ENR by Mn(VII) obeyed a secondary-order kinetics.
Modern high-resolution tandem mass spectrometry coupled with high performance liquid chromatography was used to analyze the structures of degradation products.
Four main oxidation products were identified at different pH values.
Several influencing factors, pH value, and buffer obviously affect reaction rate and products relative abundance.
Autocatalysis taking place at slightly acidic pH promotes the reaction but has no effect on the product types.
A plausible oxidation pathway for enrofloxacin with Mn(VII) was proposed.
The oxidation took place at the piperazine ring.
Structural changes to the piperazine ring include N-dealkylation, hydroxylation, and hydrolysis.
Residual antibacterial activity of the oxidative reaction solutions against nonresistant Escherichia coli reference strain DH5α is evaluated by means of quantitative bioassays.
It is noticed that the oxidation products exhibited negligible antibacterial activity just when the structures of the products changed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Yongpeng& Liu, Shiyao& Guo, Fang& Cui, Fuyi. 2015. Oxidation of Enrofloxacin with Permanganate: Kinetics, Multivariate Effects, Identification of Oxidation Products, and Determination of Residual Antibacterial Activity. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Yongpeng…[et al.]. Oxidation of Enrofloxacin with Permanganate: Kinetics, Multivariate Effects, Identification of Oxidation Products, and Determination of Residual Antibacterial Activity. Journal of Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Yongpeng& Liu, Shiyao& Guo, Fang& Cui, Fuyi. Oxidation of Enrofloxacin with Permanganate: Kinetics, Multivariate Effects, Identification of Oxidation Products, and Determination of Residual Antibacterial Activity. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر