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Effects of Self-Assembled Monolayers with Different Chemical Groups on Ovarian Cancer Cell Line Behavior In Vitro
المؤلفون المشاركون
Li, Jie
Guan, Ting
Hao, Chenjun
Li, Lihua
Zhang, Yu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In addition to serving as a physical support, the extracellular matrix (ECM) actively influences cell behavior.
However, the definitive effects of different chemical structures present in the ECM on cell behavior remain obscure.
The current study aimed to investigate the effects of different chemical structures present in the ECM on cellular physiology using the ovarian cancer cell line SKOV-3 as a model.
Self-assembled monolayers (SAMs) with different chemical modifications, including methyl (-CH3), hydroxyl (-OH), amino (-NH2), carboxyl (-COOH), and mercapto (-SH) groups, were used as microenvironmental models to explore the effects of different structures on SKOV-3 cells.
The cell morphology, cell adhesion, cytotoxicity, and functional alterations in cancer cells cultured on different SAMs were analyzed.
The results showed that SKOV-3 cells cultured on -NH2 surfaces exhibited the largest contact area, whereas those on -CH3 surfaces exhibited the smallest contact area and mostly rounded morphologies.
Additionally, -NH2 and -COOH promoted cell proliferation and adhesion, whereas CH3 inhibited adhesion, leading to G1 arrest during the cell cycle and resulting in cell apoptosis.
This study may provide useful information for reconstruction of the ECM and for controlling cell behavior in related areas of study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jie& Guan, Ting& Hao, Chenjun& Li, Lihua& Zhang, Yu. 2015. Effects of Self-Assembled Monolayers with Different Chemical Groups on Ovarian Cancer Cell Line Behavior In Vitro. Journal of Chemistry،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067625
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jie…[et al.]. Effects of Self-Assembled Monolayers with Different Chemical Groups on Ovarian Cancer Cell Line Behavior In Vitro. Journal of Chemistry No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067625
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jie& Guan, Ting& Hao, Chenjun& Li, Lihua& Zhang, Yu. Effects of Self-Assembled Monolayers with Different Chemical Groups on Ovarian Cancer Cell Line Behavior In Vitro. Journal of Chemistry. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067625
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067625
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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