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Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial
المؤلفون المشاركون
Satirapoj, Bancha
Supasyndh, Ouppatham
Kaewput, Wisit
Ruangkanchanasetr, Prajej
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Glycosaminoglycans or sulodexide has shown benefits in early experimental diabetic nephropathy (DN) models, but its efficacy in patients with early stage of DN is unknown.
Methods.
Twenty patients were randomly assigned to the placebo group and another 20 patients were randomly assigned to receive sulodexide 100 mg/day for 14 weeks.
Primary outcome was a change of urinary TGF-beta1, albuminuria, and glomerular filtration rate (GFR).
All patients had stable metabolic profiles for at least 90 days before randomization.
Results.
Urinary TGF-beta1 increased significantly in the placebo group but did not change significantly in the sulodexide group.
Additionally, the mean change of urine TGF-beta1 in the placebo group was significantly higher than that in the sulodexide group ( 8.44 ± 9.21 versus 2.17 ± 6.96 pg/mg Cr, P = 0.02 ).
Mean changes of urinary albumin were 15.05 ± 30.09 μg/mg Cr ( P = 0.038 ) in the placebo group and 13.89 ± 32.25 μg/mg Cr ( P = 0.069 ) in the sulodexide group.
No consistent patterns of side effects were observed.
Conclusion.
In this 14-week trial, benefits of sulodexide in preventing the increase of urinary TGF-beta1 were observed in patients with normoalbuminuric type 2 diabetes.
The study suggests that sulodexide treatment may provide additional renoprotection in early stage DN.
This trial is registered with TCTR20140806001.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Satirapoj, Bancha& Kaewput, Wisit& Supasyndh, Ouppatham& Ruangkanchanasetr, Prajej. 2015. Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Satirapoj, Bancha…[et al.]. Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial. Journal of Diabetes Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Satirapoj, Bancha& Kaewput, Wisit& Supasyndh, Ouppatham& Ruangkanchanasetr, Prajej. Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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