Importance of Maternal Diabetes on the Chronological Deregulation of the Intrauterine Development: An Experimental Study in Rat
المؤلفون المشاركون
Reyes-López, Alfonso
Salazar García, Marcela
Reyes Maldonado, Elba
Revilla Monsalve, María Cristina
Villavicencio Guzmán, Laura
Sánchez-Gómez, Concepción
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We investigated whether maternal diabetes induced in rats using streptozotocin (STZ) on Day 5 of pregnancy affects the intrauterine developmental timeline.
A total of 30 pregnant Sprague-Dawley diabetic rats (DRs) and 20 control rats (CRs) were used to obtain 21-day fetuses (F21) and newborn (NB) pups.
Gestational age, weight, and body size were recorded as were the maxillofacial morphometry and morphohistological characteristics of the limbs.
In DRs, pregnancy continued for ∼1.7 days, and delivery occurred 23 days postcoitus (DPC).
In this group, the number of pups was lower, and 13% had maxillofacial defects.
F21 in the DR group had lower weights and were smaller; moreover, the morphological characteristics of the maxillofacial structures, derived from the neural crest, were discordant with their chronological gestational age, resembling 18- to 19-day-old fetuses.
These deficiencies were counterbalanced in NB pups.
We conclude that hyperglycemia, which results from maternal diabetes and precedes embryo implantation, deregulates the intrauterine developmental timeline, restricts embryo-fetal growth, and primarily delays the remodeling and maturation of the structures derived from neural crest cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salazar García, Marcela& Reyes Maldonado, Elba& Revilla Monsalve, María Cristina& Villavicencio Guzmán, Laura& Reyes-López, Alfonso& Sánchez-Gómez, Concepción. 2015. Importance of Maternal Diabetes on the Chronological Deregulation of the Intrauterine Development: An Experimental Study in Rat. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salazar García, Marcela…[et al.]. Importance of Maternal Diabetes on the Chronological Deregulation of the Intrauterine Development: An Experimental Study in Rat. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salazar García, Marcela& Reyes Maldonado, Elba& Revilla Monsalve, María Cristina& Villavicencio Guzmán, Laura& Reyes-López, Alfonso& Sánchez-Gómez, Concepción. Importance of Maternal Diabetes on the Chronological Deregulation of the Intrauterine Development: An Experimental Study in Rat. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر