Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to IschemiaReperfusion Injury: Identification of Underlying Gene Expression Changes

المؤلفون المشاركون

Karck, M.
Korkmaz-Icöz, Sevil
Lehner, Alice
Li, Shiliang
Vater, Adrian
Radovits, Tamás
Hegedűs, Péter
Ruppert, Mihály
Brlecic, Paige
Szabó, Gábor
Zorn, Markus

المصدر

Journal of Diabetes Research

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-07-01

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Despite clinical studies indicating that diabetic hearts are more sensitive to ischemia/reperfusion injury, experimental data is contradictory.

Although mild diabetes prior to ischemia/reperfusion may induce a myocardial adaptation, further research is still needed.

Nondiabetic Wistar (W) and type 2 diabetic Goto-Kakizaki (GK) rats (16-week-old) underwent 45 min occlusion of the left anterior descending coronary artery and 24 h reperfusion.

The plasma glucose level was significantly higher in diabetic rats compared to the nondiabetics.

Diabetes mellitus was associated with ventricular hypertrophy and increased interstitial fibrosis.

Inducing myocardial infarction increased the glucose levels in diabetic compared to nondiabetic rats.

Furthermore, the infarct size was smaller in GK rats than in the control group.

Systolic and diastolic functions were impaired in W + MI and did not reach statistical significance in GK + MI animals compared to the corresponding controls.

Among the 125 genes surveyed, 35 genes showed a significant change in expression in GK + MI compared to W + MI rats.

Short-term diabetes promotes compensatory mechanisms that may provide cardioprotection against ischemia/reperfusion injury, at least in part, by increased antioxidants and the upregulation of the prosurvival PI3K/Akt pathway, by the downregulation of apoptotic genes, proinflammatory cytokine TNF-α, profibrogenic TGF-β, and hypertrophic marker α-actin-1.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Korkmaz-Icöz, Sevil& Lehner, Alice& Li, Shiliang& Vater, Adrian& Radovits, Tamás& Hegedűs, Péter…[et al.]. 2015. Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to IschemiaReperfusion Injury: Identification of Underlying Gene Expression Changes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1067899

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Korkmaz-Icöz, Sevil…[et al.]. Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to IschemiaReperfusion Injury: Identification of Underlying Gene Expression Changes. Journal of Diabetes Research No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1067899

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Korkmaz-Icöz, Sevil& Lehner, Alice& Li, Shiliang& Vater, Adrian& Radovits, Tamás& Hegedűs, Péter…[et al.]. Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to IschemiaReperfusion Injury: Identification of Underlying Gene Expression Changes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1067899

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1067899