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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure?
المؤلفون المشاركون
Roberts, Anna C.
Gohil, Jai
Hudson, Laura
Connolly, Kyle
Warburton, Philip
Suman, Rakesh
O’Toole, Peter
O’Regan, David J.
Turner, Neil A.
Porter, Karen E.
Riches, Kirsten
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Type 2 diabetes (T2DM) confers increased risk of endothelial dysfunction, coronary heart disease, and vulnerability to vein graft failure after bypass grafting, despite glycaemic control.
This study explored the concept that endothelial cells (EC) cultured from T2DM and nondiabetic (ND) patients are phenotypically and functionally distinct.
Cultured human saphenous vein- (SV-) EC were compared between T2DM and ND patients in parallel.
Proliferation, migration, and in vitro angiogenesis assays were performed; western blotting was used to quantify phosphorylation of Akt, ERK, and eNOS.
The ability of diabetic stimuli (hyperglycaemia, TNF-α, and palmitate) to modulate angiogenic potential of ND-EC was also explored.
T2DM-EC displayed reduced migration (~30%) and angiogenesis (~40%) compared with ND-EC and a modest, nonsignificant trend to reduced proliferation.
Significant inhibition of Akt and eNOS, but not ERK phosphorylation, was observed in T2DM cells.
Hyperglycaemia did not modify ND-EC function, but TNF-α and palmitate significantly reduced angiogenic capacity (by 27% and 43%, resp.), effects mimicked by Akt inhibition.
Aberrancies of EC function may help to explain the increased risk of SV graft failure in T2DM patients.
This study highlights the importance of other potentially contributing factors in addition to hyperglycaemia that may inflict injury and long-term dysfunction to the homeostatic capacity of the endothelium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roberts, Anna C.& Gohil, Jai& Hudson, Laura& Connolly, Kyle& Warburton, Philip& Suman, Rakesh…[et al.]. 2015. Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure?. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roberts, Anna C.…[et al.]. Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure?. Journal of Diabetes Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roberts, Anna C.& Gohil, Jai& Hudson, Laura& Connolly, Kyle& Warburton, Philip& Suman, Rakesh…[et al.]. Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure?. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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