Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications
المؤلفون المشاركون
Medina, Reinhold J.
O'Neill, Christina L.
Stitt, Alan W.
Rajasekar, Poojitha
Eeles, Lydia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-28
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The vascular complications of diabetes significantly impact the quality of life and mortality in diabetic patients.
Extensive evidence from various human clinical trials has clearly established that a period of poor glycemic control early in the disease process carries negative consequences, such as an increase in the development and progression of vascular complications that becomes evident many years later.
Importantly, intensive glycemic control established later in the disease process cannot reverse or slow down the onset or progression of diabetic vasculopathy.
This has been named the glycemic memory phenomenon.
Scientists have successfully modelled glycemic memory using various in vitro and in vivo systems.
This review emphasizes that oxidative stress and accumulation of advanced glycation end products are key factors driving glycemic memory in endothelial cells.
Furthermore, various epigenetic marks have been proposed to closely associate with vascular glycemic memory.
In addition, we comment on the importance of endothelial progenitors and their role as endogenous vasoreparative cells that are negatively impacted by the diabetic milieu and may constitute a “carrier” of glycemic memory.
Considering the potential of endothelial progenitor-based cytotherapies, future studies on their glycemic memory are warranted to develop epigenetics-based therapeutics targeting diabetic vascular complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rajasekar, Poojitha& O'Neill, Christina L.& Eeles, Lydia& Stitt, Alan W.& Medina, Reinhold J.. 2015. Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1067909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rajasekar, Poojitha…[et al.]. Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications. Journal of Diabetes Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1067909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rajasekar, Poojitha& O'Neill, Christina L.& Eeles, Lydia& Stitt, Alan W.& Medina, Reinhold J.. Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1067909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر