NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia
المؤلفون المشاركون
Su, Hua
Zhang, Chun
Gao, Pan
He, Fang-Fang
Tang, Hui
Lei, Chun-Tao
Chen, Shan
Meng, Xian-Fang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease, and previously we demonstrated that NALP3 inflammasome was involved in the pathogenesis of DN.
Here we investigated the mechanisms of NALP3 inflammasome activation in podocyte injury during DN.
We found that, besides the activation of NALP3 inflammasome and upregulated thioredoxin-interacting protein (TXNIP), the glomerular expression of gp 91 phox , a subunit of NADPH oxidase, was enhanced in DN mice simultaneously.
Inhibiting NADPH oxidase abrogated NALP3 inflammasome activation, and IL-1β production and eventually protected podocytes from high glucose- (HG-) induced injury.
TXNIP, an inhibitor of thioredoxin, acts as a suppressor for antioxidant defense system.
Our observation indicated that in HG-exposed podocytes genetic deletion of TXNIP by shRNA reversed gp 91 phox overexpression and alleviated the injury of podocyte.
Collectively, our findings proposed that HG-induced NADPH oxidase activation was driven by TXNIP which subsequently triggered NALP3 inflammasome activation in podocytes and ultimately led to podocyte injury, and blocking TXNIP/NADPH oxidase signaling may be a promising treatment for DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Pan& He, Fang-Fang& Tang, Hui& Lei, Chun-Tao& Chen, Shan& Meng, Xian-Fang…[et al.]. 2015. NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Pan…[et al.]. NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia. Journal of Diabetes Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1067928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Pan& He, Fang-Fang& Tang, Hui& Lei, Chun-Tao& Chen, Shan& Meng, Xian-Fang…[et al.]. NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1067928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر