Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes
المؤلفون المشاركون
Mizushige, Tomoko
Nishijima, Yoko
Yano, Yuichiro
Sakata, Koji
Hayakawa, Manabu
Nishiyama, Akira
Kobori, Hiroyuki
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The aims of this study were (1) to examine the renoprotective effects of alogliptin and (2) to establish urinary angiotensinogen (AGT) as a prognostic marker of renoprotective effects of alogliptin in patients with type 2 diabetes (T2D).
Methods.
In 43 patients with T2D (18 women, 66.1 ± 1.71 years), 25 mg/day of alogliptin was added to the traditional hypoglycemic agents and/or nondrug treatments.
Urinary concentrations of albumin (Alb) and AGT, normalized by urinary concentrations of creatinine (Cr) (UAlbCR and UAGTCR, respectively), were measured before and after the 12-week alogliptin treatment.
Results.
Alogliptin treatment tended to decrease UAlbCR ( 99.6 ± 26.8 versus 114.6 ± 36.0 mg/g Cr, P = 0.198 ).
Based on % change in UAlbCR, patients were divided into two groups, responders ( < - 25 % ) and nonresponders ( ≥ - 25 % ), and a logistic analysis of UAGTCR before treatment showed cutoff value of 20.8 µg/g Cr.
When all patients were redivided into two groups, those with higher values of UAGTCR before the treatment (Group H, n = 20 ) and those with lower values (Group L), Group H showed significantly decreased UAlbCR in response to alogliptin ( - 14.6 ± 8.6 versus + 22.8 ± 16.8 % , P = 0.033 ).
Conclusion.
Urinary AGT could be a prognostic marker of renoprotective effects of alogliptin in patients with T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mizushige, Tomoko& Kobori, Hiroyuki& Nishijima, Yoko& Yano, Yuichiro& Sakata, Koji& Hayakawa, Manabu…[et al.]. 2015. Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067935
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mizushige, Tomoko…[et al.]. Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067935
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mizushige, Tomoko& Kobori, Hiroyuki& Nishijima, Yoko& Yano, Yuichiro& Sakata, Koji& Hayakawa, Manabu…[et al.]. Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067935
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067935
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر