The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy
المؤلفون المشاركون
Magrinelli, Francesca
Briani, Chiara
Romano, Marcello
Ruggero, Susanna
Toffanin, Elisabetta
Triolo, Giuseppa
Peter, George Chummar
Lauriola, Matteo Francesco
Tamburin, Stefano
Praitano, Marialuigia
Zanette, Giampietro
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Diabetic peripheral neuropathy (DPN) is a frequent complication of type 2 diabetes mellitus (DM) and may involve small and large peripheral nerve fibers.
Recent evidence suggests a role of cytokines in DPN.
The paper is aimed at exploring whether the serum concentration of cytokines is associated with small and large nerve fiber function and with neuropathic pain (NP).
We recruited a group of 32 type 2 DM patients who underwent serum cytokines (TNF-α, IL-2, IL-4, IL-6, and IL-10) dosage as well as electrodiagnostic and quantitative sensory testing (QST) assessment to explore damage to large and small nerve fibers.
Raised serum levels of IL-6 and IL-10 correlated with markers of large nerve fiber sensory and motor axonal damage.
Raised IL-10 serum level was associated with signs of motor nerve demyelination.
No differences were found in pain characteristics and electrodiagnostic and QST markers of small nerve fiber function in relation to cytokines serum levels.
IL-6 and IL-10 serum levels were associated with large nerve fiber damage but not to small fibers function or NP.
IL-6 and IL-10 cytokines might play a role in the pathogenesis of nerve fiber damage or represent a compensatory or neuroprotective mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Magrinelli, Francesca& Briani, Chiara& Romano, Marcello& Ruggero, Susanna& Toffanin, Elisabetta& Triolo, Giuseppa…[et al.]. 2015. The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067945
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Magrinelli, Francesca…[et al.]. The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067945
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Magrinelli, Francesca& Briani, Chiara& Romano, Marcello& Ruggero, Susanna& Toffanin, Elisabetta& Triolo, Giuseppa…[et al.]. The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067945
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067945
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر