Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats

المؤلفون المشاركون

Mihailović, Mirjana
Arambašić Јovanović, Jelena
Uskoković, Aleksandra
Grdović, Nevena
Dinić, Svetlana
Vidović, Senka
Poznanović, Goran
Mujić, Ibrahim
Vidaković, Melita

المصدر

Journal of Diabetes Research

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-06-29

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

The aim of this study was to assess the in vivo effects of the extract of the medicinal mushroom, Lactarius deterrimus, when administered (60 mg/kg, i.p.) daily for four weeks to streptozotocin- (STZ-) induced diabetic rats.

Diabetic rats treated with the L.

deterrimus extract displayed several improved biochemical parameters in the circulation: reduced hyperglycemia, lower triglyceride concentration and reduced glycated hemoglobin, glycated serum protein, and advanced glycation end product (AGE) levels.

This treatment also adjusted the diabetes-induced redox imbalance.

Thus, higher activities of the antioxidative enzymes, superoxide dismutase, and catalase in the circulation were accompanied by increased levels of free intracellular thiols and glutathionylated proteins after treatment with the L.

deterrimus extract.

In addition to a systemic antioxidant effect, the administration of the extract to diabetic rats also had a positive localized effect on pancreatic islets where it decreased AGE formation, and increased the expression of chemokine CXCL12 protein that mediates the restoration of β-cell population through the activation of the serine/threonine-specific Akt protein kinase prosurvival pathway.

As a result, the numbers of proliferating cell nuclear antigen- (PCNA-) and insulin-positive β-cells were increased.

These results show that the ability of the L.

deterrimus extract to alleviate oxidative stress and increase β-cell mass represents a therapeutic potential for diabetes management.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mihailović, Mirjana& Arambašić Јovanović, Jelena& Uskoković, Aleksandra& Grdović, Nevena& Dinić, Svetlana& Vidović, Senka…[et al.]. 2015. Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067949

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Mihailović, Mirjana…[et al.]. Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067949

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mihailović, Mirjana& Arambašić Јovanović, Jelena& Uskoković, Aleksandra& Grdović, Nevena& Dinić, Svetlana& Vidović, Senka…[et al.]. Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067949

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1067949