Adipokines as Drug Targets in Diabetes and Underlying Disturbances
المؤلفون المشاركون
Camara, Niels Olsen Saraiva
Andrade-Oliveira, Vinícius
Moraes-Vieira, Pedro M.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetes and obesity are worldwide health problems.
White fat dynamically participates in hormonal and inflammatory regulation.
White adipose tissue is recognized as a multifactorial organ that secretes several adipose-derived factors that have been collectively termed “adipokines.” Adipokines are pleiotropic molecules that gather factors such as leptin, adiponectin, visfatin, apelin, vaspin, hepcidin, RBP4, and inflammatory cytokines, including TNF and IL-1β, among others.
Multiple roles in metabolic and inflammatory responses have been assigned to these molecules.
Several adipokines contribute to the self-styled “low-grade inflammatory state” of obese and insulin-resistant subjects, inducing the accumulation of metabolic anomalies within these individuals, including autoimmune and inflammatory diseases.
Thus, adipokines are an interesting drug target to treat autoimmune diseases, obesity, insulin resistance, and adipose tissue inflammation.
The aim of this review is to present an overview of the roles of adipokines in different immune and nonimmune cells, which will contribute to diabetes as well as to adipose tissue inflammation and insulin resistance development.
We describe how adipokines regulate inflammation in these diseases and their therapeutic implications.
We also survey current attempts to exploit adipokines for clinical applications, which hold potential as novel approaches to drug development in several immune-mediated diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Andrade-Oliveira, Vinícius& Camara, Niels Olsen Saraiva& Moraes-Vieira, Pedro M.. 2015. Adipokines as Drug Targets in Diabetes and Underlying Disturbances. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Andrade-Oliveira, Vinícius…[et al.]. Adipokines as Drug Targets in Diabetes and Underlying Disturbances. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Andrade-Oliveira, Vinícius& Camara, Niels Olsen Saraiva& Moraes-Vieira, Pedro M.. Adipokines as Drug Targets in Diabetes and Underlying Disturbances. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر