Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

المؤلفون المشاركون

Correa-Burrows, P.
Albala, C.
Blanco, Estela
Gahagan, Sheila
Reyes, Marcela
Burrows, Raquel

المصدر

Journal of Diabetes Research

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-07-27

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Objective.

To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors.

Methods.

In 667 adolescents (16.8 ± 0.3 y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured.

Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry.

Family history of type 2 diabetes (FHDM) was reported.

We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis.

IR was defined as HOMA-IR values above the cutoff.

We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses.

Results.

Of the participants, 16% were obese and 9.4 % met criteria for MetS.

The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6.

Based on this value, 16.3% of participants had IR.

Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR.

FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR.

Conclusions.

In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Burrows, Raquel& Correa-Burrows, P.& Reyes, Marcela& Blanco, Estela& Albala, C.& Gahagan, Sheila. 2015. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067998

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Burrows, Raquel…[et al.]. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067998

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Burrows, Raquel& Correa-Burrows, P.& Reyes, Marcela& Blanco, Estela& Albala, C.& Gahagan, Sheila. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067998

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1067998