Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors
Joint Authors
Correa-Burrows, P.
Albala, C.
Blanco, Estela
Gahagan, Sheila
Reyes, Marcela
Burrows, Raquel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors.
Methods.
In 667 adolescents (16.8 ± 0.3 y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured.
Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry.
Family history of type 2 diabetes (FHDM) was reported.
We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis.
IR was defined as HOMA-IR values above the cutoff.
We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses.
Results.
Of the participants, 16% were obese and 9.4 % met criteria for MetS.
The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6.
Based on this value, 16.3% of participants had IR.
Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR.
FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR.
Conclusions.
In adolescents, HOMA-IR ≥ 2.6 was associated with greater cardiometabolic risk.
American Psychological Association (APA)
Burrows, Raquel& Correa-Burrows, P.& Reyes, Marcela& Blanco, Estela& Albala, C.& Gahagan, Sheila. 2015. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067998
Modern Language Association (MLA)
Burrows, Raquel…[et al.]. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067998
American Medical Association (AMA)
Burrows, Raquel& Correa-Burrows, P.& Reyes, Marcela& Blanco, Estela& Albala, C.& Gahagan, Sheila. Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067998