Cardiovascular Mortality in Type 2 Diabetes Patients with Incident Exposure to Insulin Glargine
المؤلفون المشاركون
Reghina, Aura Diana
Fica, Simona
Ioacara, Sorin
Guja, Cristian
Martin, Sorina
Sirbu, Anca
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The study investigated the impact of insulin glargine exposure on cardiovascular mortality in type 2 diabetes patients with incident insulin initiation.
All consecutive diabetes patients aged >40 years were screened at their first diabetes outpatient visit between 01/01/2001 and 12/31/2008 (n=79869).
Exclusion criteria restricted the cohort to 4990 incident insulin users, aged 40–79 years, who were followed up for death until 12/31/2011.
Baseline was defined 6 months after insulin initiation.
Adjusted time-dependent competing risk regression analysis was performed.
Mean baseline age was 62±9 years, with mean follow-up of 4.7±1.9 years.
During 23179 person-years of exposure time, there were 887 deaths (521 cardiovascular).
Glargine cumulative time exposure significantly lowered overall cardiovascular, subhazard ratio (SHR) 0.963 (CI 95% 0.944–0.981, p<0.001), and myocardial infarction mortality, SHR 0.945 (CI 95% 0.899–0.994, p=0.028), but not stroke mortality.
Glargine cumulative dose exposure (10,000 IU increments) significantly lowered cardiovascular mortality, SHR 0.977 (CI 95% 0.960–0.993, p=0.006), but not for myocardial infarction and stroke.
Both cumulative dose and time exposure to insulin glargine were associated with lower cardiovascular mortality.
The effect was mostly driven by myocardial infarction end point, supporting the concept of macrovascular benefit for basal analogue insulin use in type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ioacara, Sorin& Guja, Cristian& Reghina, Aura Diana& Martin, Sorina& Sirbu, Anca& Fica, Simona. 2015. Cardiovascular Mortality in Type 2 Diabetes Patients with Incident Exposure to Insulin Glargine. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ioacara, Sorin…[et al.]. Cardiovascular Mortality in Type 2 Diabetes Patients with Incident Exposure to Insulin Glargine. Journal of Diabetes Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ioacara, Sorin& Guja, Cristian& Reghina, Aura Diana& Martin, Sorina& Sirbu, Anca& Fica, Simona. Cardiovascular Mortality in Type 2 Diabetes Patients with Incident Exposure to Insulin Glargine. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر