Umbilical Cord-Derived Mesenchymal Stem Cells Inhibit Cadherin-11 Expression by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
المؤلفون المشاركون
Zhao, Cheng
Zhang, Lu
Kong, Wei
Liang, Jun
Xu, Xinyun
Wu, Hongyan
Hua, Bingzhu
Wang, Hong
Feng, Xuebing
Sun, Ling-Yun
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study aimed to determine whether umbilical cord-derived mesenchymal stem cells (UCMSC) regulate Cadherin-11 (CDH11) expression by fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA).
FLS were isolated from the synovium of RA and osteoarthritis (OA) patients.
FLS from RA patients were cocultured with UCMSC in a transwell system.
CDH11 mRNA levels in FLS were tested, and levels of soluble factors expressed by UCMSC, such as indoleamine 2,3-dioxygenase (IDO), hepatocyte growth factor (HGF), and interleukin- (IL-) 10, were determined.
IDO, HGF, and IL-10 were upregulated in cocultures, so that appropriate inhibitors were added before determination of CDH11 expression.
The effects of UCMSC on arthritis were investigated in the collagen-induced arthritis (CIA) model in Wistar rats.
FLS from RA patients expressed higher CDH11 levels than those from OA patients, and this effect was suppressed by UCMSC.
The inhibitory effect of UCMSC on CDH11 expression by FLS was abolished by suppression of IL-10 activity.
CDH11 expression in synovial tissues was higher in the context of CIA than under basal conditions, and this effect was prevented by UCMSC administration.
IL-10 mediates the inhibitory effect of UCMSC on CDH11 expression by FLS, and this mechanism might be targeted to ameliorate arthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Cheng& Zhang, Lu& Kong, Wei& Liang, Jun& Xu, Xinyun& Wu, Hongyan…[et al.]. 2015. Umbilical Cord-Derived Mesenchymal Stem Cells Inhibit Cadherin-11 Expression by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Cheng…[et al.]. Umbilical Cord-Derived Mesenchymal Stem Cells Inhibit Cadherin-11 Expression by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Cheng& Zhang, Lu& Kong, Wei& Liang, Jun& Xu, Xinyun& Wu, Hongyan…[et al.]. Umbilical Cord-Derived Mesenchymal Stem Cells Inhibit Cadherin-11 Expression by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068365
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر