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Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2neu Tumor
المؤلفون المشاركون
Lamolinara, Alessia
Stramucci, Lorenzo
Hysi, Albana
Iezzi, Manuela
Marchini, Cristina
Mariotti, Marianna
Amici, Augusto
Curcio, Claudia
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination.
Nevertheless, intramuscular electroporation is the most common delivery method for ECTM vaccination.
In this study we assessed whether intradermal administration could deliver the vaccine into different cell types and we analyzed the evolution of tissue infiltrate elicited by the vaccination protocol.
Intradermal electroporation (EP) vaccination resulted in transfection of different skin layers, as well as mononuclear cells.
Additionally, we observed a marked recruitment of reactive infiltrates mainly 6–24 hours after treatment and inflammatory cells included CD11c+.
Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice.
A significant delay in transplantable tumor onset was observed in both BALB/c ( p ≤ 0 ,0003) and BALB-neuT mice ( p = 0 ,003).
Moreover, BALB-neuT mice displayed slow tumor growth as compared to control group ( p < 0 ,0016).
In addition, while in vivo cytotoxic response was observed only in BALB/c mice, a significant antibody response was achieved in both mouse models.
Our results identify intradermal EP vaccination as a promising method for delivering Her2/neu DNA vaccine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lamolinara, Alessia& Stramucci, Lorenzo& Hysi, Albana& Iezzi, Manuela& Marchini, Cristina& Mariotti, Marianna…[et al.]. 2015. Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2neu Tumor. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068379
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lamolinara, Alessia…[et al.]. Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2neu Tumor. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068379
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lamolinara, Alessia& Stramucci, Lorenzo& Hysi, Albana& Iezzi, Manuela& Marchini, Cristina& Mariotti, Marianna…[et al.]. Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2neu Tumor. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068379
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068379
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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