The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease
المؤلفون المشاركون
Mabbott, Neil Andrew
Bradford, Barry Matthew
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Prions are a unique group of proteinaceous pathogens which cause neurodegenerative disease and can be transmitted by a variety of exposure routes.
After peripheral exposure, the accumulation and replication of prions within secondary lymphoid organs are obligatory for their efficient spread from the periphery to the brain where they ultimately cause neurodegeneration and death.
Mononuclear phagocytes (MNP) are a heterogeneous population of dendritic cells (DC) and macrophages.
These cells are abundant throughout the body and display a diverse range of roles based on their anatomical locations.
For example, some MNP are strategically situated to provide a first line of defence against pathogens by phagocytosing and destroying them.
Conventional DC are potent antigen presenting cells and migrate via the lymphatics to the draining lymphoid tissue where they present the antigens to lymphocytes.
The diverse roles of MNP are also reflected in various ways in which they interact with prions and in doing so impact on disease pathogenesis.
Indeed, some studies suggest that prions exploit conventional DC to infect the host.
Here we review our current understanding of the influence of MNP in the pathogenesis of the acquired prion diseases with particular emphasis on the role of conventional DC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mabbott, Neil Andrew& Bradford, Barry Matthew. 2015. The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mabbott, Neil Andrew& Bradford, Barry Matthew. The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mabbott, Neil Andrew& Bradford, Barry Matthew. The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر