Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes
المؤلفون المشاركون
Schreiner, Wolfgang
Ribarics, Reiner
Ilieva, Nevena
Kenn, Michael
Karch, Rudolf
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-05
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
MHC α-helices form the antigen-binding cleft and are of particular interest for immunological reactions.
To monitor these helices in molecular dynamics simulations, we applied a parsimonious fragment-fitting method to trace the axes of the α-helices.
Each resulting axis was fitted by polynomials in a least-squares sense and the curvature integral was computed.
To find the appropriate polynomial degree, the method was tested on two artificially modelled helices, one performing a bending movement and another a hinge movement.
We found that second-order polynomials retrieve predefined parameters of helical motion with minimal relative error.
From MD simulations we selected those parts of α-helices that were stable and also close to the TCR/MHC interface.
We monitored the curvature integral, generated a ruled surface between the two MHC α-helices, and computed interhelical area and surface torsion, as they changed over time.
We found that MHC α-helices undergo rapid but small changes in conformation.
The curvature integral of helices proved to be a sensitive measure, which was closely related to changes in shape over time as confirmed by RMSD analysis.
We speculate that small changes in the conformation of individual MHC α-helices are part of the intrinsic dynamics induced by engagement with the TCR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribarics, Reiner& Kenn, Michael& Karch, Rudolf& Ilieva, Nevena& Schreiner, Wolfgang. 2015. Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1068386
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribarics, Reiner…[et al.]. Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes. Journal of Immunology Research No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1068386
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribarics, Reiner& Kenn, Michael& Karch, Rudolf& Ilieva, Nevena& Schreiner, Wolfgang. Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1068386
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068386
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر