Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma
المؤلفون المشاركون
Gluhovschi, Cristina
Gluhovschi, Gheorghe
Petrica, Ligia
Velciov, Silvia
Gluhovschi, Adrian
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Pregnancy is a physiological condition that requires immune tolerance to the product of conception.
Systemic lupus erythematosus (SLE) is a disease with well-represented immune mechanisms that disturb immune tolerance.
The association of pregnancy with systemic lupus erythematosus creates a particular immune environment in which the immune tolerance specific of pregnancy is required to coexist with alterations of the immune system caused by SLE.
The main role is played by T regulatory (Treg) cells, which attempt to regulate and adapt the immune system of the mother to the new conditions of pregnancy.
Other components of the immune system also participate to maintain maternal-fetal immune tolerance.
If the immune system of pregnant women with SLE is not able to maintain maternal immune tolerance to the fetus, pregnancy complications (miscarriage, fetal hypotrophy, and preterm birth) or maternal complications (preeclampsia or activation of SLE, especially in conditions of lupus nephritis) may occur.
In certain situations this can be responsible for neonatal lupus.
At the same time, it must be noted that during pregnancy, the immune system is able to achieve immune tolerance while maintaining the anti-infectious immune capacity of the mother.
Immunological monitoring of pregnancy during SLE, as well as of the mother’s disease, is required.
It is important to understand immune tolerance to grafts in transplant pathology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gluhovschi, Cristina& Gluhovschi, Gheorghe& Petrica, Ligia& Velciov, Silvia& Gluhovschi, Adrian. 2015. Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gluhovschi, Cristina…[et al.]. Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gluhovschi, Cristina& Gluhovschi, Gheorghe& Petrica, Ligia& Velciov, Silvia& Gluhovschi, Adrian. Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر