The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren’s Syndrome
المؤلفون المشاركون
Sun, Xiaolin
Zhu, Lei
Jia, Ru-lin
Li, Linbo
He, Jing
Yang, Yuqin
Jin, Yuebo
Liu, Xu
Liu, Yanying
Long, Li
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Objective.
Th17 cells have been demonstrated to play an important role in the onset and development of primary Sjögren’s syndrome (pSS).
In this study, we evaluated the expansion and clinical significance of circulating CD4+CD161+ T cell and its “effector” (CD4+CD25−CD161+ T cell) and “regulatory” (CD4+CD25+CD161+ T cell) subpopulations.
Methods.
Fifty-eight pSS patients and 16 healthy controls (HCs) were recruited in our study.
The cell populations and intracellular IL-17 expression were analyzed by flow cytometry.
The disease activity was evaluated by the EULAR-SS Disease Activity Index (ESSDAI).
Autoantibodies were measured by ELISA or indirect immunofluorescence assay.
Results.
The CD161+ T cell fractions showed higher proportions of IL-17-producing cells.
The frequencies of the overall CD4+CD161+ T cell population and its effector subset were positively correlated with disease activity parameters and more severe disease manifestations.
A significant elevation of the CD4+CD25+CD161+ T cell subpopulation was observed in the peripheral blood of pSS patients compared to HCs and this subset showed decreased regulatory functions compared with the CD4+CD25+CD161− population.
Conclusion.
Circulating CD4+CD161+ T cell populations associated with pSS disease activity and severity.
These cells might be involved in the development of pSS and could be potential therapeutic targets in the treatment of pSS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Linbo& He, Jing& Zhu, Lei& Yang, Yuqin& Jin, Yuebo& Jia, Ru-lin…[et al.]. 2015. The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren’s Syndrome. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Linbo…[et al.]. The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren’s Syndrome. Journal of Immunology Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Linbo& He, Jing& Zhu, Lei& Yang, Yuqin& Jin, Yuebo& Jia, Ru-lin…[et al.]. The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren’s Syndrome. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر