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The Effects of Bromocriptine on Preventing Postpartum Flare in Systemic Lupus Erythematosus Patients from South China
المؤلفون المشاركون
Yang, Xiuyan
Qian, Qiu
Liuqin, Liang
Hao, Li
Shiwen, Yuan
Dongying, Chen
Fan, Lian
Xu, Hanshi
Ye, Yujin
Zhan, Zhongping
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
Prolactin plays an important role on the disease flare of postpartum SLE patients.
76 pregnant SLE patients were enrolled in this study to evaluate the efficacy of bromocriptine (an inhibitor of prolactin secretion) on preventing the postpartum disease relapse.
Methods.
Patients were randomly divided into the treatment group (bromocriptine, 2.5 mg oral, twice a day for 14 days after delivery) and the control group.
All the patients were followed up for 12 months.
Clinical features were recorded every 4 weeks.
Serum prolactin and estradiol levels were measured at the second week and the second month after delivery.
The endpoint of the study was disease relapse and defined when SLEDAI score increased by ≥3 points from the antenatal baseline.
Results.
(1) Serum levels of prolactin and estradiol decreased significantly in bromocriptine treatment group at the second week ( P < 0.001 ) and second month ( P < 0.05 ) after delivery compared to control group.
(2) The relapse rate of the treatment group was lower than the control group ( χ 2 = 4.68 , P = 0.0305 ).
Conclusions.
Two weeks of oral bromocriptine treatment in postpartum SLE patients may relieve the disease from hyperprolactinemia and hyperestrogenemia and may be beneficial in preventing the patients from disease relapse.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qian, Qiu& Liuqin, Liang& Hao, Li& Shiwen, Yuan& Zhan, Zhongping& Dongying, Chen…[et al.]. 2015. The Effects of Bromocriptine on Preventing Postpartum Flare in Systemic Lupus Erythematosus Patients from South China. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068439
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qian, Qiu…[et al.]. The Effects of Bromocriptine on Preventing Postpartum Flare in Systemic Lupus Erythematosus Patients from South China. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068439
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qian, Qiu& Liuqin, Liang& Hao, Li& Shiwen, Yuan& Zhan, Zhongping& Dongying, Chen…[et al.]. The Effects of Bromocriptine on Preventing Postpartum Flare in Systemic Lupus Erythematosus Patients from South China. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068439
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068439
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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