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Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-26 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus
المؤلفون المشاركون
Estrada-Parra, Sergio
Estrada-Garcia, Iris
Wong-Baeza, Carlos
Tescucano, Alonso
Astudillo, Horacio
Reséndiz, Albany
Landa, Carla
España, Luis
Serafín-López, Jeanet
Flores-Romo, Leopoldo
Wong, Carlos
Baeza, Isabel
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens.
Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies against nonbilayer phospholipid arrangements.
As the effect of these liposomes on the innate immune response is unknown and innate immune system activation is necessary for efficient antibody formation, we evaluated the effect of these liposomes on Toll-like receptor (TLR) signaling, cytokine production, proinflammatory gene expression, and T, NKT, dendritic, and B cells.
Liposomes induce TLR-4- and, to a lesser extent, TLR-2/TLR-6-dependent signaling in TLR-expressing human embryonic kidney (HEK) cells and bone marrow-derived macrophages.
Mice with the lupus-like disease had increased serum concentrations of proinflammatory cytokines, C3a and C5a; they also had more TLR-4-expressing splenocytes, a higher expression of genes associated with TRIF-dependent TLR-4-signaling and complement activation, and a lower expression of apoptosis-related genes, compared to healthy mice.
The percentage of NKT and the percentage and activation of dendritic and B2 cells were also increased.
Thus, TLR-4 and TLR-2/TLR-6 activation by nonbilayer phospholipid arrangements triggers an inflammatory response that could contribute to autoantibody production and the generation of a lupus-like disease in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wong-Baeza, Carlos& Tescucano, Alonso& Astudillo, Horacio& Reséndiz, Albany& Landa, Carla& España, Luis…[et al.]. 2015. Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-26 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068456
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wong-Baeza, Carlos…[et al.]. Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-26 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. Journal of Immunology Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068456
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wong-Baeza, Carlos& Tescucano, Alonso& Astudillo, Horacio& Reséndiz, Albany& Landa, Carla& España, Luis…[et al.]. Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-26 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068456
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068456
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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