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Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives
المؤلفون المشاركون
Barton, James C.
Barton, J. Clayborn
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We performed a retrospective study of autoimmune conditions (ACs) in 235 hemochromatosis probands at diagnosis by analyzing age, sex, ACs, history of first-degree family members with ACs (FH), diabetes, heavy ethanol consumption, elevated serum ALT/AST, nonalcoholic fatty liver disease, viral hepatitis, cirrhosis, iron removed to achieve iron depletion (QFe), and positivity for human leukocyte antigen (HLA) haplotypes A ∗ 01 , B ∗ 08 ; A ∗ 02 , B ∗ 44 ; A ∗ 03 , B ∗ 07 ; A ∗ 03 , B ∗ 14 ; and A ∗ 29 , B ∗ 44 .
There were 138 men (58.7%).
Median followup was 19.6 y.
One or more of 19 ACs were diagnosed in each of 35 probands (14.9%).
Prevalences of Hashimoto’s thyroiditis, rheumatoid arthritis, and ankylosing spondylitis were 8.1% (95% CI: [5.1, 12.5]), 1.7% [0.6, 4.6], and 0.0085 [0.0015, 0.0337], respectively.
Eighteen probands (7.7%) had a FH.
Eight probands with ACs had 9 family members with ACs.
In a logistic regression, ACs were less likely in men (odds ratio (OR) 0.3 [0.1, 0.6]) and more likely in probands with a FH (OR 4.1 [1.4, 11.8]).
Overall ACs risk was not significantly associated with QFe or HLA haplotypes.
Estimated survival of probands with and without ACs did not differ significantly.
We conclude that ACs are common in hemochromatosis probands, especially women and probands with a FH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barton, James C.& Barton, J. Clayborn. 2015. Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068481
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barton, James C.& Barton, J. Clayborn. Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068481
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barton, James C.& Barton, J. Clayborn. Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068481
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068481
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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