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Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination
المؤلفون المشاركون
Kanduc, Darja
Fasano, Candida
Capone, Giovanni
Pesce Delfino, Antonella
Calabrò, Michele
Polimeno, Lorenzo
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Although rare, adverse events may associate with anti-poliovirus vaccination thus possibly hampering global polio eradication worldwide.
Objective.
To design peptide-based anti-polio vaccines exempt from potential cross-reactivity risks and possibly able to reduce rare potential adverse events such as the postvaccine paralytic poliomyelitis due to the tendency of the poliovirus genome to mutate.
Methods.
Proteins from poliovirus type 1, strain Mahoney, were analyzed for amino acid sequence identity to the human proteome at the pentapeptide level, searching for sequences that (1) have zero percent of identity to human proteins, (2) are potentially endowed with an immunologic potential, and (3) are highly conserved among poliovirus strains.
Results.
Sequence analyses produced a set of consensus epitopic peptides potentially able to generate specific anti-polio immune responses exempt from cross-reactivity with the human host.
Conclusion.
Peptide sequences unique to poliovirus proteins and conserved among polio strains might help formulate a specific and universal anti-polio vaccine able to react with multiple viral strains and exempt from the burden of possible cross-reactions with human proteins.
As an additional advantage, using a peptide-based vaccine instead of current anti-polio DNA vaccines would eliminate the rare post-polio poliomyelitis cases and other disabling symptoms that may appear following vaccination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kanduc, Darja& Fasano, Candida& Capone, Giovanni& Pesce Delfino, Antonella& Calabrò, Michele& Polimeno, Lorenzo. 2015. Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kanduc, Darja…[et al.]. Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kanduc, Darja& Fasano, Candida& Capone, Giovanni& Pesce Delfino, Antonella& Calabrò, Michele& Polimeno, Lorenzo. Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068515
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