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Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks
المؤلفون المشاركون
Morris, Carlos F. M.
Tahir, Muhammad
Arshid, Samina
Castro, Mariana S.
Fontes, Wagner
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Inflammatory cascades and mechanisms are ubiquitous during host responses to various types of insult.
Biological models and interventional strategies have been devised as an effort to better understand and modulate inflammation-driven injuries.
Amongst those the two-hit model stands as a plausible and intuitive framework that explains some of the most frequent clinical outcomes seen in injuries like trauma and sepsis.
This model states that a first hit serves as a priming event upon which sequential insults can build on, culminating on maladaptive inflammatory responses.
On a different front, ischemic preconditioning (IPC) has risen to light as a readily applicable tool for modulating the inflammatory response to ischemia and reperfusion.
The idea is that mild ischemic insults, either remote or local, can cause organs and tissues to be more resilient to further ischemic insults.
This seemingly contradictory role that the two models attribute to a first inflammatory hit, as priming in the former and protective in the latter, has set these two theories on opposing corners of the literature.
The present review tries to reconcile both models by showing that, rather than debunking each other, each framework offers unique insights in understanding and modulating inflammation-related injuries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morris, Carlos F. M.& Tahir, Muhammad& Arshid, Samina& Castro, Mariana S.& Fontes, Wagner. 2015. Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morris, Carlos F. M.…[et al.]. Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morris, Carlos F. M.& Tahir, Muhammad& Arshid, Samina& Castro, Mariana S.& Fontes, Wagner. Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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