FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy
المؤلفون المشاركون
Stelmaszczyk-Emmel, Anna
Zawadzka-Krajewska, Anna
Głodkowska-Mrówka, Eliza
Demkow, Urszula
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Over the last decades allergic diseases has become a major health problem worldwide.
The only specific treatment to date is allergen specific immunotherapy (ASIT).
Although it was shown that ASIT generates allergen-tolerant T cells, detailed mechanism underlying its activity is still unclear and there is no reliable method to monitor its effectiveness.
The aim of our study was to evaluate ASIT influence on the frequency of forkhead box P3 (FoxP3) Tregs in allergic children with various clinical manifestations.
The relative number of FoxP3 Tregs in 32 blood samples from allergic children at baseline and/or after 1 year of ASIT was assessed by flow cytometry.
In the entire studied group, the percentage of FoxP3 Tregs did not increase 1 year after ASIT.
Nevertheless, the percentage of FoxP3 Tregs after ASIT significantly increased in children with respiratory allergy (conjunctivitis, asthma, and rhinitis) coexisting with nonrespiratory manifestations (food allergy and/or atopic dermatitis), whereas, in patients with respiratory allergy only, the percentage of FoxP3 Tregs decreased.
To the best of our knowledge, this is the first report showing various differential FoxP3 Tregs response to ASIT in allergic children.
FoxP3 Tregs number could be useful in treatment monitoring.
Further studies are warranted to confirm these observations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stelmaszczyk-Emmel, Anna& Zawadzka-Krajewska, Anna& Głodkowska-Mrówka, Eliza& Demkow, Urszula. 2015. FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068568
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stelmaszczyk-Emmel, Anna…[et al.]. FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068568
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stelmaszczyk-Emmel, Anna& Zawadzka-Krajewska, Anna& Głodkowska-Mrówka, Eliza& Demkow, Urszula. FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068568
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068568
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر