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Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus
المؤلفون المشاركون
Dong, Guang Fu
Zhang, Xiao
He, De Ning
Li, Ling
Zhang, Guang Feng
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purposes.
To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes.
Methods.
The B cell subsets and LRs expression were determined by flow cytometry and confocal microscopy, and F-actin expression was examined by confocal microscopy.
Results.
CD27+IgD+ B cell subsets were significantly decreased while CD38+CD95+ B cell subsets increased in SLE patients.
The LRs levels of B cells were remarkably increased and positively correlated with SLEDAI and anti-dsDNA titer in SLE patients.
The expression level of LRs was significantly higher in CD38+ B cells than CD38− B cells and negatively correlated with C3 levels.
The increased expression of LRs was associated with reduced expression of F-actin in the B cells from active SLE patients.
Furthermore, in vitro treatment of the cells with A771726 reduced the expression level of LRs, attenuated the overaggregation of LRs, and normalized the distribution of F-actin.
Conclusions.
There were abnormalities in B cell subsets and LRs and F-actin expression of B cell from SLE patients.
Modulation of B cell expression of LRs and F-actin by LEF could be a potential therapeutic target for SLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Guang Fu& Zhang, Xiao& He, De Ning& Li, Ling& Zhang, Guang Feng. 2015. Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068608
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Guang Fu…[et al.]. Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068608
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Guang Fu& Zhang, Xiao& He, De Ning& Li, Ling& Zhang, Guang Feng. Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068608
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068608
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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