Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage
المؤلفون المشاركون
Silva, Priscila de Matos
Bier, Julia
Paiatto, Lisiery Negrini
Galdino Albuquerque, Cassia
Lopes Souza, Caique
Fernandes, Luis Gustavo Romani
Tamashiro, Wirla Maria da Silva Cunha
Simioni, Patricia Ucelli
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-12
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance.
It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens.
Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity.
However, the mechanisms that support this dual role are not entirely clear.
Recent studies have shown that DCs can be manipulated ex vivo in order to trigger their tolerogenic profile, what can be a tool to be used in clinical trials aiming the treatment of various diseases and the prevention of transplant rejection.
In this sense, the blockage of costimulatory molecules on DC, in the attempt of inhibiting the second signal in the immunological synapse, can be considered as one of the main strategies under development.
This review brings an update on current therapies using tolerogenic dendritic cells modulated with costimulatory blockers with the aim of reducing transplant rejection.
However, although there are current clinical trials using tolerogenic DC to treat allograft rejection, the actual challenge is to modulate these cells in order to maintain a permanent tolerogenic profile.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Silva, Priscila de Matos& Bier, Julia& Paiatto, Lisiery Negrini& Galdino Albuquerque, Cassia& Lopes Souza, Caique& Fernandes, Luis Gustavo Romani…[et al.]. 2015. Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068623
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Silva, Priscila de Matos…[et al.]. Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage. Journal of Immunology Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068623
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Silva, Priscila de Matos& Bier, Julia& Paiatto, Lisiery Negrini& Galdino Albuquerque, Cassia& Lopes Souza, Caique& Fernandes, Luis Gustavo Romani…[et al.]. Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068623
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068623
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر