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Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity
المؤلفون المشاركون
López-Morales, Carlos A.
Miranda-Hernández, Mariana P.
Ramírez-Ibáñez, Nancy D.
Piña-Lara, Nelly
Revilla-Beltri, Jorge
Molina-Pérez, Aarón
Pérez, Néstor O.
Medina-Rivero, Emilio
Flores-Ortiz, Luis F.
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rituximab is a chimeric monoclonal antibody employed for the treatment of CD20-positive B-cell non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis and microscopic polyangiitis.
It binds specifically to the CD20 antigen expressed on pre-B and consequently on mature B-lymphocytes of both normal and malignant cells, inhibiting their proliferation through apoptosis, CDC, and ADCC mechanisms.
The immunomodulatory activity of rituximab is closely related to critical quality attributes that characterize its chemical composition and spatial configuration, which determine the recognition of CD20 and the binding to receptors or factors involved in its effector functions, while regulating the potential immunogenic response.
Herein, we present a physicochemical and biological characterization followed by a pharmacodynamics and immunogenicity study to demonstrate comparability between two products containing rituximab.
The physicochemical and biological characterization revealed that both products fit within the same response intervals exhibiting the same degree of variability.
With regard to clinical response, both products depleted CD20+ B-cells until posttreatment recovery and no meaningful differences were found in their pharmacodynamic profiles.
The evaluation of anti-chimeric antibodies did not show differential immunogenicity among products.
Overall, these data confirm that similarity of critical quality attributes results in a comparable immunomodulatory activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miranda-Hernández, Mariana P.& López-Morales, Carlos A.& Ramírez-Ibáñez, Nancy D.& Piña-Lara, Nelly& Pérez, Néstor O.& Molina-Pérez, Aarón…[et al.]. 2015. Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068639
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miranda-Hernández, Mariana P.…[et al.]. Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068639
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miranda-Hernández, Mariana P.& López-Morales, Carlos A.& Ramírez-Ibáñez, Nancy D.& Piña-Lara, Nelly& Pérez, Néstor O.& Molina-Pérez, Aarón…[et al.]. Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068639
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068639
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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