BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients
المؤلفون المشاركون
Carlsson, Malin
Hellmark, Thomas
Segelmark, Mårten
Lindberg, Ulrika
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Patients with cystic fibrosis (CF) colonized with Pseudomonas aeruginosa (P.
aeruginosa) have worse prognosis compared with patients who are not.
BPI-ANCA is an anti-neutrophil cytoplasmic antibody against BPI (bactericidal/permeability increasing protein) correlating with P.
aeruginosa colonization and adverse long time prognosis.
Whether it provides additional information as compared to standard anti-P.
aeruginosa serology tests is not known.
117 nontransplanted CF patients at the CF centre in Lund, Sweden, were followed prospectively for ten years.
Bacterial colonisation was classified according to the Leeds criteria.
IgA BPI-ANCA was compared with assays for antibodies against alkaline protease (AP), Elastase (ELA), and Exotoxin A (ExoA).
Lung function and patient outcome, alive, lung transplanted, or dead, were registered.
BPI-ANCA showed the highest correlation with lung function impairment with an r-value of 0.44.
Forty-eight of the 117 patients were chronically colonized with P.
aeruginosa.
Twenty of these patients experienced an adverse outcome.
Receiver operator curve (ROC) analysis revealed that this could be predicted by BPI-ANCA (AUC = 0.77), ( p = 0.002 ) to a better degree compared with serology tests.
BPI-ANCA correlates better with lung function impairment and long time prognosis than anti-P.
aeruginosa serology and has similar ability to identify patients with chronic P.
aeruginosa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lindberg, Ulrika& Carlsson, Malin& Hellmark, Thomas& Segelmark, Mårten. 2015. BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lindberg, Ulrika…[et al.]. BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lindberg, Ulrika& Carlsson, Malin& Hellmark, Thomas& Segelmark, Mårten. BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر