Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus
المؤلفون المشاركون
Zhang, Jian-Ying
Shi, Guixiu
Dai, Liping
Liu, Weihong
Liu, Yuan
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Systemic lupus erythematosus (SLE) is one of the systemic autoimmune diseases characterized by the polyclonal autoantibody production.
The human homologue of the mouse double minute 2 (MDM2) is well known as the negative regulator of p53.
MDM2 has been reported to be overexpressed in SLE animal model and to promote SLE.
Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE patients.
Methods.
Anti-MDM2 antibody in sera from 43 SLE patients and 69 healthy persons was investigated by ELISA.
Positive samples were further confirmed by western blotting.
The immunological feathers of anti-MDM2 positive sera were analyzed by indirect immunofluorescence assay.
Anti-p53 was also investigated in SLE patients by ELISA, and the correlation of anti-MDM2 and anti-p53 was analyzed.
Results.
The presence of anti-MDM2 in SLE patients was 23.30%, much higher than normal healthy persons (4.30%).
These anti-MDM2 positive sera present a nuclear staining pattern.
The presence of anti-p53 in SLE patients was 39.50%, and the titer of anti-MDM2 was positively correlated with anti-p53 in SLE patients.
Conclusions.
Anti-MDM2 autoantibody was detected at high prevalence in SLE patients.
The detection of anti-MDM2 in SLE patients should be clinically useful.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yuan& Dai, Liping& Liu, Weihong& Shi, Guixiu& Zhang, Jian-Ying. 2015. Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068655
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yuan…[et al.]. Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068655
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yuan& Dai, Liping& Liu, Weihong& Shi, Guixiu& Zhang, Jian-Ying. Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068655
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068655
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر