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Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study
المؤلفون المشاركون
Cardona-Muñoz, Ernesto German
Nava, Arnulfo
Salazar-Paramo, Mario
Davalos-Rodriguez, Ingrid Patricia
Rodriguez-Jimenez, Norma Alejandra
Vasquez-Jimenez, Jose Clemente
Brambila-Tapia, Aniel Jessica Leticia
De la Cerda-Trujillo, Liliana Faviola
Díaz-Rizo, Valeria
Díaz-González, Viviana
Zavala-Cerna, María Guadalupe
Gonzalez-Lopez, Laura
Vázquez-Del Mercado, Mónica
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the effect of anti-TNF agents plus synthetic disease modifying antirheumatic drugs (DMARDs) versus DMARDs alone for ankylosing spondylitis (AS) with reduced pulmonary function vital capacity (FVC%).
Methods.
In an observational study, we included AS who had FVC% <80% at baseline.
Twenty patients were taking DMARDs and 16 received anti-TNF + DMARDs.
Outcome measures: changes in FVC%, BASDAI, BASFI, 6-minute walk test (6MWT), Borg scale after 6MWT, and St.
George’s Respiratory Questionnaire at 24 months.
Results.
Both DMARDs and anti-TNF + DMARDs groups had similar baseline values in FVC%.
Significant improvement was achieved with anti-TNF + DMARDs in FVC%, at 24 months, when compared to DMARDs alone (P=0.04).
Similarly, patients in anti-TNF + DMARDs group had greater improvement in BASDAI, BASFI, Borg scale, and 6MWT when compared to DMARDs alone.
After 2 years of follow-up, 14/16 (87.5%) in the anti-TNF + DMARDs group achieved the primary outcome: FVC% ≥80%, compared with 11/20 (55%) in the DMARDs group (P=0.04).
Conclusions.
Patients with anti-TNF + DMARDs had a greater improvement in FVC% and cardiopulmonary scales at 24 months compared with DMARDs.
This preliminary study supports the fact that anti-TNF agents may offer additional benefits compared to DMARDs in patients with AS who have reduced FVC%.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocha-Muñoz, Alberto Daniel& Brambila-Tapia, Aniel Jessica Leticia& Zavala-Cerna, María Guadalupe& Vasquez-Jimenez, Jose Clemente& De la Cerda-Trujillo, Liliana Faviola& Vázquez-Del Mercado, Mónica…[et al.]. 2015. Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocha-Muñoz, Alberto Daniel…[et al.]. Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocha-Muñoz, Alberto Daniel& Brambila-Tapia, Aniel Jessica Leticia& Zavala-Cerna, María Guadalupe& Vasquez-Jimenez, Jose Clemente& De la Cerda-Trujillo, Liliana Faviola& Vázquez-Del Mercado, Mónica…[et al.]. Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068659
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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