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Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein
المؤلفون المشاركون
Kameda, Takahiro
Ohkawa, Ryunosuke
Yano, Kouji
Usami, Yoko
Miyazaki, Akari
Matsuda, Kazuyuki
Kawasaki, Kenji
Sugano, Mitsutoshi
Kubota, Tetsuo
Tozuka, Minoru
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
High-density lipoprotein (HDL) has protective effects against the development of atherosclerosis; these effects include reverse cholesterol transport, antioxidant ability, and anti-inflammation.
Myeloperoxidase (MPO) secreted by macrophages in atherosclerotic lesions generates tyrosyl radicals in apolipoprotein A-I (apoA-I) molecules, inducing the formation of apoA-I/apoA-II heterodimers through the tyrosine-tyrosine bond in HDL.
Functional characterization of HDL oxidized by MPO could provide useful information about the significance of apoA-I/apoA-II heterodimers measurement.
We investigated the effects of MPO-induced oxidation on the antiatherogenic functions of HDL as described above.
The antioxidant ability of HDL, estimated as the effect on LDL oxidation induced by copper sulfate, was not significantly affected after MPO oxidation.
HDL reduced THP-1 monocyte migration by suppressing the stimulation of human umbilical vein endothelial cells induced by lipopolysaccharide (LPS).
MPO-oxidized HDL also showed inhibition of THP-1 chemotaxis, but the extent of inhibition was significantly attenuated compared to intact HDL.
MPO treatment did not affect the cholesterol efflux capacity of HDL from [3H]-cholesterol-laden macrophages derived from THP-1 cells.
The principal effect of MPO oxidation on the antiatherogenic potential of HDL would be the reduction of anti-inflammatory ability, suggesting that measurement of apoA-I/apoA-II heterodimers might be useful to estimate anti-inflammatory ability of HDL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kameda, Takahiro& Ohkawa, Ryunosuke& Yano, Kouji& Usami, Yoko& Miyazaki, Akari& Matsuda, Kazuyuki…[et al.]. 2015. Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein. Journal of Lipids،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kameda, Takahiro…[et al.]. Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein. Journal of Lipids No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kameda, Takahiro& Ohkawa, Ryunosuke& Yano, Kouji& Usami, Yoko& Miyazaki, Akari& Matsuda, Kazuyuki…[et al.]. Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein. Journal of Lipids. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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