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Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets
المؤلفون المشاركون
Horng, H. E.
Liao, Shu-Hsien
Su, Yu-Kai
Chen, Kuen-Lin
Yang, Hong-Chang
Chen, Jean-Hong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
An assay of biomarkers consisting of alpha-fetoprotein (AFP) is reported.
Real-time measurements of the effective relaxation time τeff, when the biofunctionalized magnetic nanoparticles (BMNs) were conjugating with biotargets, were made.
The BMNs are anti-alpha-fetoprotein (antiAFP) coated onto dextran-coated iron oxide nanoparticles labeled as Fe3O4-antiAFP.
It was found that the effective relaxation time, τeff, increases as the association of AFP and Fe3O4-antiAFP evolves.
We attribute this to the enhanced Brownian motion of BMNs when magnetic clusters are present during the conjugation.
We found that saturation magnetization, Ms, increases when the concentration of AFP increases.
This is due to the fact that more magnetic clusters are associated in the reagent, and therefore the Ms increases when the concentration of AFP increases.
The change of effective relaxation time and saturation magnetization shows a behavior of logistic function, which provides a foundation for assaying an unknown amount of biomolecules.
Thus, we demonstrate sensitive platforms for detecting AFP by characterizing τeff.
The detection platform is robust and easy to use and shows promise for further use in assaying a broad number of biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liao, Shu-Hsien& Chen, Jean-Hong& Su, Yu-Kai& Chen, Kuen-Lin& Horng, H. E.& Yang, Hong-Chang. 2015. Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liao, Shu-Hsien…[et al.]. Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets. Journal of Nanomaterials No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liao, Shu-Hsien& Chen, Jean-Hong& Su, Yu-Kai& Chen, Kuen-Lin& Horng, H. E.& Yang, Hong-Chang. Assaying Biomarkers via Real-Time Measurements of the Effective Relaxation Time of Biofunctionalized Magnetic Nanoparticles Associated with Biotargets. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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