Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy
المؤلفون المشاركون
Thavendiranathan, Paaladinesh
Rakowski, Harry
Calleja, Anna
Poulin, Frédéric
Khorolsky, Ciril
Shariat, Masoud
Bedard, Philippe L.
Amir, Eitan
McDonald, Michael
Delgado, Diego
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Right ventricular (RV) dysfunction during cancer therapy related cardiotoxicity and its prognostic implications have not been examined.
Aim.
We sought to determine the incidence and prognostic value of RV dysfunction at time of LV defined cardiotoxicity.
Methods.
We retrospectively identified 30 HER2+ female patients with breast cancer treated with trastuzumab (± anthracycline) who developed cardiotoxicity and had a diagnostic quality transthoracic echocardiography.
LV ejection fraction (LVEF), RV fractional area change (RV FAC), and peak systolic longitudinal strain (for both LV and RV) were measured on echocardiograms at the time of cardiotoxicity and during follow-up.
Thirty age balanced precancer therapy and HER2+ breast cancer patients were used as controls.
Results.
In the 30 patients with cardiotoxicity (mean ± SD age 54 ± 12 years) RV FAC was significantly lower (42 ± 7 versus 47 ± 6%, P=0.01) compared to controls.
RV dysfunction defined by global longitudinal strain (GLS < −20.3%) was seen in 40% (n=12).
During follow-up in 16 out of 30 patients (23 ± 15 months), there was persistent LV dysfunction (EF < 55%) in 69% (n=11).
Concomitant RV dysfunction at the time of LV cardiotoxicity was associated with reduced recovery of LVEF during follow-up although this was not statistically significant.
Conclusion.
RV dysfunction at the time of LV cardiotoxicity is frequent in patients with breast cancer receiving trastuzumab therapy.
Despite appropriate management, LV dysfunction persisted in the majority at follow-up.
The prognostic value of RV dysfunction at the time of cardiotoxicity warrants further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calleja, Anna& Poulin, Frédéric& Khorolsky, Ciril& Shariat, Masoud& Bedard, Philippe L.& Amir, Eitan…[et al.]. 2015. Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy. Journal of Oncology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calleja, Anna…[et al.]. Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy. Journal of Oncology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calleja, Anna& Poulin, Frédéric& Khorolsky, Ciril& Shariat, Masoud& Bedard, Philippe L.& Amir, Eitan…[et al.]. Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069578
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر