Comment on “School-Based Obesity Prevention Intervention in Chilean Children: Effective in Controlling, but not Reducing Obesity”

الملخص EN

We read with interest the article “School-Based Obesity Prevention Intervention in Chilean Children: Effective in Controlling, but not Reducing Obesity” [1], hereafter “the article.” In the article [1], nine schools were randomized into intervention and control groups according to the socioeconomic conditions of the children (a stratified randomization design at the cluster level), resulting in five schools in the intervention condition and four schools in the control.

The intervention consisted of training teachers to deliver content on healthy eating and to improve the quality of physical education classes.

The primary outcome was change in BMI Z score between baseline and follow-up.

This is a typical cluster randomized controlled trial (cRCT) in which the inferences are intended to apply at the individual (student) level while randomization is at the cluster (school) level [2, 3].

In cRCTs, the potential lack of independence among individuals in the same cluster, that is, intracluster correlation (ICC), creates special methodological issues in both design and analysis.

Any individual level analysis without considering the clustering is invalid [3].

Unfortunately, the article [1] ignored the clustering in its sample size estimation and final data analysis, which potentially increased type I and type II error rates and put their conclusions in doubt.