Safety and Efficacy of Adding Fixed-Combination BrinzolamideTimolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma
المؤلفون المشاركون
Hommer, Anton
Hubatsch, Douglas A.
Cano-Parra, Juan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the safety and efficacy of adding brinzolamide 1%/timolol maleate 0.5% fixed combination (BTFC) to a prostaglandin analog (PGA).
Methods.
This was a 12-week, open-label, single-arm study of patients with open-angle glaucoma or ocular hypertension with intraocular pressure (IOP) not sufficiently controlled after ≥4 weeks of PGA monotherapy.
The primary outcome was mean IOP change from baseline at week 12.
Other outcomes included IOP change from baseline at week 4, percentage of patients achieving IOP ≤18 mmHg at week 12, and patient experience survey responses at week 12.
Results.
Forty-seven patients were enrolled and received treatment.
The most commonly used PGAs were latanoprost (47%) and travoprost (32%).
Mean ± SD IOP was decreased at week 12 (17.2 ± 4.1 mmHg) compared with baseline (23.1 ± 3.0 mmHg; P<0.001, paired t-test); IOP at week 4 was 17.2 ± 3.3 mmHg.
At week 12, 70% of patients achieved IOP ≤18 mmHg.
Patient-reported symptoms (e.g., pain and redness) were mostly unchanged from baseline.
Twenty-eight adverse events (AEs) were reported; the most frequently reported AE was headache (3 events in 2 patients).
Conclusion.
Adjunctive BTFC + PGA therapy was effective and well tolerated.
IOP decreased by 6 mmHg at weeks 4 and 12.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hommer, Anton& Hubatsch, Douglas A.& Cano-Parra, Juan. 2015. Safety and Efficacy of Adding Fixed-Combination BrinzolamideTimolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069643
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hommer, Anton…[et al.]. Safety and Efficacy of Adding Fixed-Combination BrinzolamideTimolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma. Journal of Ophthalmology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069643
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hommer, Anton& Hubatsch, Douglas A.& Cano-Parra, Juan. Safety and Efficacy of Adding Fixed-Combination BrinzolamideTimolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069643
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069643
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر