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Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis
المؤلفون المشاركون
Yoshida, Junko
Wicks, Robert T.
Zambrano, Andrea I.
Javaherian, Kashi
Grossman, Rachel
Daoud, Yassine J.
Brem, Henry
Stark, Walter J.
Gehlbach, Peter L.
Tyler, Betty
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We assessed the antiangiogenic effects of subconjunctival injection of Fc-endostatin (FcE) using a human vascular endothelial growth factor-induced rabbit corneal neovascularization model.
Angiogenesis was induced in rabbit corneas through intrastromal implantations of VEGF polymer implanted 2 mm from the limbus.
NZW rabbits were separated into groups receiving twice weekly subconjunctival injections of either saline; 25 mg/mL bevacizumab; 2 mg/mL FcE; or 20 mg/mL FcE.
Corneas were digitally imaged at 5 time points.
An angiogenesis index (AI) was calculated (vessel length (mm) × vessel number score) for each observation.
All treatment groups showed a significant decrease in the vessel length and AI compared to saline on all observation days (P<0.001).
By day 15, FcE 2 inhibited angiogenesis significantly better than FcE 20 (P<0.01).
There was no significant difference between FcE 2 and BV, although the values trended towards significantly increased inhibition by BV.
BV was a significantly better inhibitor than FcE 20 by day 8 (P<0.01).
FcE was safe and significantly inhibited new vessel growth in a rabbit corneal neovascularization model.
Lower concentration FcE 2 exhibited better inhibition than FcE 20, consistent with previous FcE studies referencing a biphasic dose-response curve.
Additional studies are necessary to further elucidate the efficacy and clinical potential of this novel angiogenesis inhibitor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoshida, Junko& Wicks, Robert T.& Zambrano, Andrea I.& Tyler, Betty& Javaherian, Kashi& Grossman, Rachel…[et al.]. 2015. Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069646
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoshida, Junko…[et al.]. Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. Journal of Ophthalmology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069646
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoshida, Junko& Wicks, Robert T.& Zambrano, Andrea I.& Tyler, Betty& Javaherian, Kashi& Grossman, Rachel…[et al.]. Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069646
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069646
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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