Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy
المؤلفون المشاركون
Prea, Selwyn M.
Chan, Elsa C.
Liu, Guei-Sheung
Bui, Bang V.
Dusting, Gregory J.
Vingrys, Algis J.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries.
The advanced neovascular (or “wet”) form of the disease is responsible for severe and aggressive loss of central vision.
Current treatments aim to seal off leaky blood vessels via laser therapy or to suppress vessel leakage and neovascular growth through intraocular injections of antibodies that target vascular endothelial growth factor (VEGF).
However, the long-term success of anti-VEGF therapy can be hampered by limitations such as low or variable efficacy, high frequency of administration (usually monthly), potentially serious side effects, and, most importantly, loss of efficacy with prolonged treatment.
Gene transfer of endogenous antiangiogenic proteins is an alternative approach that has the potential to provide long-term suppression of neovascularization and/or excessive vascular leakage in the eye.
Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes.
In addition, a clinical trial in patients suffering from advanced neovascular AMD has provided proof-of-concept for successful gene transfer.
In this mini review, we summarize current theories pertaining to the application of gene therapy for neovascular AMD and the potential benefits when used in conjunction with endogenous antiangiogenic proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prea, Selwyn M.& Chan, Elsa C.& Dusting, Gregory J.& Vingrys, Algis J.& Bui, Bang V.& Liu, Guei-Sheung. 2015. Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prea, Selwyn M.…[et al.]. Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy. Journal of Ophthalmology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1069670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prea, Selwyn M.& Chan, Elsa C.& Dusting, Gregory J.& Vingrys, Algis J.& Bui, Bang V.& Liu, Guei-Sheung. Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر