Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study
المؤلفون المشاركون
Parekh, Mohit
Franch, Antonella
Birattari, Federica
Dal Mas, Gloria
Lužnik, Zala
Ferrari, Stefano
Ponzin, Diego
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
To compare stromal riboflavin concentration after three corneal cross-linking (CXL) imbibition procedures: standard (EpiOff), transepithelial corneal (EpiOn), and iontophoresis-assisted technique (Ionto) using 0.1% hypotonic riboflavin phosphate.
Methods.
Randomized open-label pilot clinical study.
Twelve corneas/12 patients with advanced keratoconus were randomly divided into 4 groups for CXL ( n = 3 ).
The corneas underwent imbibition with standard riboflavin EpiOff and with enhanced riboflavin solution (RICROLIN+) EpiOff, EpiOn, and iontophoresis techniques.
Thereafter, deep anterior lamellar keratectomy procedure was performed and the obtained debrided corneal tissues were frozen.
The maximal intrastromal riboflavin concentration was measured by high-performance liquid chromatography/mass spectrometry (mcg/dg).
Results.
The mean stromal concentration of riboflavin was 2.02 ± 0.72 mcg/dg in EpiOff group, 4.33 ± 0.12 mcg/g in EpiOff-RICROLIN+ group, 0.63 ± 0.21 mcg/dg in EpiOn-RICROLIN+ group, and 1.15 ± 0.27 mcg/dg in iontophoresis RICROLIN+ group.
A 7-fold decrease in intrastromal riboflavin concentration was observed comparing EpiOn-RICROLIN+ and EpiOff-RICROLIN+ groups.
Conclusion.
The present pilot study indicates that both transepithelial CXL techniques in combination with hypotonic enhanced riboflavin formulation (RICROLIN+) were still inferior to the standard CXL technique; however, larger clinical studies to further validate the results are needed and in progress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franch, Antonella& Birattari, Federica& Dal Mas, Gloria& Lužnik, Zala& Parekh, Mohit& Ferrari, Stefano…[et al.]. 2015. Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franch, Antonella…[et al.]. Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study. Journal of Ophthalmology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1069840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franch, Antonella& Birattari, Federica& Dal Mas, Gloria& Lužnik, Zala& Parekh, Mohit& Ferrari, Stefano…[et al.]. Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر