![](/images/graphics-bg.png)
Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study
المؤلفون المشاركون
Parekh, Mohit
Franch, Antonella
Birattari, Federica
Dal Mas, Gloria
Lužnik, Zala
Ferrari, Stefano
Ponzin, Diego
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
To compare stromal riboflavin concentration after three corneal cross-linking (CXL) imbibition procedures: standard (EpiOff), transepithelial corneal (EpiOn), and iontophoresis-assisted technique (Ionto) using 0.1% hypotonic riboflavin phosphate.
Methods.
Randomized open-label pilot clinical study.
Twelve corneas/12 patients with advanced keratoconus were randomly divided into 4 groups for CXL ( n = 3 ).
The corneas underwent imbibition with standard riboflavin EpiOff and with enhanced riboflavin solution (RICROLIN+) EpiOff, EpiOn, and iontophoresis techniques.
Thereafter, deep anterior lamellar keratectomy procedure was performed and the obtained debrided corneal tissues were frozen.
The maximal intrastromal riboflavin concentration was measured by high-performance liquid chromatography/mass spectrometry (mcg/dg).
Results.
The mean stromal concentration of riboflavin was 2.02 ± 0.72 mcg/dg in EpiOff group, 4.33 ± 0.12 mcg/g in EpiOff-RICROLIN+ group, 0.63 ± 0.21 mcg/dg in EpiOn-RICROLIN+ group, and 1.15 ± 0.27 mcg/dg in iontophoresis RICROLIN+ group.
A 7-fold decrease in intrastromal riboflavin concentration was observed comparing EpiOn-RICROLIN+ and EpiOff-RICROLIN+ groups.
Conclusion.
The present pilot study indicates that both transepithelial CXL techniques in combination with hypotonic enhanced riboflavin formulation (RICROLIN+) were still inferior to the standard CXL technique; however, larger clinical studies to further validate the results are needed and in progress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Franch, Antonella& Birattari, Federica& Dal Mas, Gloria& Lužnik, Zala& Parekh, Mohit& Ferrari, Stefano…[et al.]. 2015. Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Franch, Antonella…[et al.]. Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study. Journal of Ophthalmology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1069840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Franch, Antonella& Birattari, Federica& Dal Mas, Gloria& Lužnik, Zala& Parekh, Mohit& Ferrari, Stefano…[et al.]. Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)