Joint Effect of CFH and ARMS2HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population
المؤلفون المشاركون
Fang, Kai
Li, Juan
Gao, Pei
Qin, Xueying
Yu, Wenzhen
Chen, Qing
Huang, Lvzhen
Li, Xiaoxin
Chen, Dafang
Hu, Yonghua
Tian, Jun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
The etiology of neovascular age-related macular degeneration (nAMD) cannot be completely explained by identified environmental risk factors or single-locus gene variants.
This study was to explore the potential interactions among gene variants on nAMD in Chinese population.
Methods.
43 SNPs located in different genes were genotyped in 932 Chinese individuals (464 nAMD patients and 468 controls).
We explored the potential interactions among gene variants using generalized multifactor dimensionality reduction (GMDR) algorithm and the method to measure the departure from the additivity model.
Results.
The joint effect that involved CFH rs1061170 and HTRA1 rs3793917 was shown statistically significant (P < 0.001) with the highest cross-validation consistency (10/10) and the best testing balanced accuracy (64.50%).
In addition, based on the method to measure the departure from the additivity model, the synergy index (S) was 2.63 (1.09–6.38) and the attributable proportion due to interaction (AP) was 55.7% (21.4%–89.9%), which suggested that a common pathway may exist for these genes for nAMD.
Those who carried CC for rs3793917 and TC/CC for rs1061170 were at the highest risk of nAMD (OR: 9.76, 95% CI: 4.65–20.51).
Conclusions.
Evidence that the joint effect that involved CFH and ARMS2/HTRA1 may contribute to the risk of neovascular AMD in Chinese population was obtained.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fang, Kai& Gao, Pei& Tian, Jun& Qin, Xueying& Yu, Wenzhen& Li, Juan…[et al.]. 2015. Joint Effect of CFH and ARMS2HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fang, Kai…[et al.]. Joint Effect of CFH and ARMS2HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. Journal of Ophthalmology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fang, Kai& Gao, Pei& Tian, Jun& Qin, Xueying& Yu, Wenzhen& Li, Juan…[et al.]. Joint Effect of CFH and ARMS2HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر