Clinical Variation of Plasmodium falciparum eba-175, ama-1, and msp-3 Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso
المؤلفون المشاركون
Tiono, Alfred B.
Soulama, Issiaka
Sermé, Samuel S.
Konate, Amadou T.
Bougouma, Edith C. Christiane
Diarra, Amidou
Nebie, Issa
Ouédraogo, Alphonse
Sirima, Sodiomon B.
المصدر
Journal of Parasitology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The association between P.
falciparum eba-175, ama-1, and msp-3 polymorphism in the pathogenicity of malaria disease was investigated.
We therefore compared the prevalence of different alleles between symptomatic and asymptomatic malarial children under five years of age living in Burkina Faso.
Blood filter papers were collected during the 2008 malaria transmission season from 228 symptomatic and 199 asymptomatic children under five years of age.
All patients were living in the rural area of Saponé at about 50 km from Ouagadougou, the capital city of Burkina Faso.
P.
falciparum parasite DNA was extracted using QIAGEN kits and the alleles diversity was assessed by a nested PCR.
PCR products were then digested by restriction enzymes based on already described polymorphic regions of the eba-175, ama-1, and msp-3 genes.
The individual alleles eba-175_FCR3 and msp-3_K1 frequencies were statistically higher (p<0.0001) in the asymptomatic group compared to the symptomatic ones.
No statistically significant difference was noted in the prevalence of ama-1-3D7, ama-1-K1, and ama-1-HB3 genotypes between the two groups (p>0.05).
The comparative analysis of P.
falciparum genotypes indicated that the polymorphism in eba-175 and msp-3 genotypes varied between asymptomatic and symptomatic clinical groups and may contribute to the pathogenesis of malaria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soulama, Issiaka& Sermé, Samuel S.& Bougouma, Edith C. Christiane& Diarra, Amidou& Tiono, Alfred B.& Ouédraogo, Alphonse…[et al.]. 2015. Clinical Variation of Plasmodium falciparum eba-175, ama-1, and msp-3 Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso. Journal of Parasitology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soulama, Issiaka…[et al.]. Clinical Variation of Plasmodium falciparum eba-175, ama-1, and msp-3 Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso. Journal of Parasitology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soulama, Issiaka& Sermé, Samuel S.& Bougouma, Edith C. Christiane& Diarra, Amidou& Tiono, Alfred B.& Ouédraogo, Alphonse…[et al.]. Clinical Variation of Plasmodium falciparum eba-175, ama-1, and msp-3 Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso. Journal of Parasitology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر