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Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes
المؤلفون المشاركون
Kayraldız, Ahmet
Dönbak, Lale
Yavuz Kocaman, Ayşe
Köker, Esra
Gökçe, Şule
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Dirithromycin antibiotic is a 14-membered lactone ring macrolide and is widely used in medicine to treat many different types of bacterial infections.
In the present study, the possible genotoxicity of dirithromycin was evaluated in cultured human lymphocytes by using sister chromatid exchanges (SCEs), chromosome aberration (CA), and micronucleus (MN) tests and also cell proliferation kinetics such as mitotic index (MI), replication index (RI), and nuclear division index (NDI) were analyzed for cytotoxicity.
Cell cultures were treated with four different concentrations of dirithromycin (37.75, 67.50, 125, and 250 µg/mL) for 24 and 48 h periods.
Dirithromycin significantly induced SCE and MN frequency at all concentrations in both 24 and 48 h treated cells.
In addition, CA level has been markedly increased in the cells treated with almost all concentrations of dirithromycin for 24 (except 37.75 µg/mL) and 48 h treatment periods as compared to control.
However, MI, RI, and NDI values were not affected by the dirithromycin treatment (p > 0.05).
The results of this study indicated that dirithromycin treatment caused genetic damage by increasing the level of cytogenetic endpoints, suggesting its genotoxic and mutagenic action on human lymphocytes in vitro.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kayraldız, Ahmet& Dönbak, Lale& Yavuz Kocaman, Ayşe& Köker, Esra& Gökçe, Şule. 2015. Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes. Journal of Toxicology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1070385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kayraldız, Ahmet…[et al.]. Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes. Journal of Toxicology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1070385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kayraldız, Ahmet& Dönbak, Lale& Yavuz Kocaman, Ayşe& Köker, Esra& Gökçe, Şule. Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes. Journal of Toxicology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1070385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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