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A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance
المؤلفون المشاركون
Timothy, William
Rashid Ali, Muhammad Redzwan S.
Parameswaran, Uma
Bird, Elspeth
Wilkes, Christopher S.
Lee, Wai Khew
Yeo, Tsin Wen
Anstey, Nicholas M.
Ralph, Anna P.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
The burden of tuberculosis is high in eastern Malaysia, and rates of Mycobacterium tuberculosis drug resistance are poorly defined.
Our objectives were to determine M.
tuberculosis susceptibility and document management after receipt of susceptibility results.
Methods.
Prospective study of adult outpatients with smear-positive pulmonary tuberculosis (PTB) in Sabah, Malaysia.
Additionally, hospital clinicians accessed the reference laboratory for clinical purposes during the study.
Results.
176 outpatients were enrolled; 173 provided sputum samples.
Mycobacterial culture yielded M.
tuberculosis in 159 (91.9%) and nontuberculous Mycobacterium (NTM) in three (1.7%).
Among outpatients there were no instances of multidrug resistant M.
tuberculosis (MDR-TB).
Seven people (4.5%) had isoniazid resistance (INH-R); all were switched to an appropriate second-line regimen for varying durations (4.5–9 months).
Median delay to commencement of the second-line regimen was 13 weeks.
Among 15 inpatients with suspected TB, 2 had multidrug resistant TB (one extensively drug resistant), 2 had INH-R, and 4 had NTM.
Conclusions.
Current community rates of MDR-TB in Sabah are low.
However, INH-resistance poses challenges, and NTM is an important differential diagnosis in this setting, where smear microscopy is the usual diagnostic modality.
To address INH-R management issues in our setting, we propose an algorithm for the treatment of isoniazid-resistant PTB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rashid Ali, Muhammad Redzwan S.& Parameswaran, Uma& Timothy, William& Bird, Elspeth& Wilkes, Christopher S.& Lee, Wai Khew…[et al.]. 2015. A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1070398
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rashid Ali, Muhammad Redzwan S.…[et al.]. A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance. Journal of Tropical Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1070398
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rashid Ali, Muhammad Redzwan S.& Parameswaran, Uma& Timothy, William& Bird, Elspeth& Wilkes, Christopher S.& Lee, Wai Khew…[et al.]. A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1070398
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070398
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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