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Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach
المؤلفون المشاركون
Mishra, B. N.
Singh, Satarudra Prakash
Roopendra, Kriti
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Despite the wealth of information regarding genetics of the causative parasite and experimental immunology of the cutaneous leishmaniasis, there is currently no licensed vaccine against it.
In the current study, a two-level data mining strategy was employed, to screen the Leishmania major genome for promising vaccine candidates.
First, we screened a set of 25 potential antigens from 8312 protein coding sequences, based on presence of signal peptides, GPI anchors, and consensus antigenicity predictions.
Second, we conducted a comprehensive immunogenic analysis of the 25 antigens based on epitopes predicted by NetCTL tool.
Interestingly, results revealed that candidate antigen number 1 (LmjF.03.0550) had greater number of potential T cell epitopes, as compared to five well-characterized control antigens (CSP-Plasmodium falciparum, M1 and NP-Influenza A virus, core protein-Hepatitis B virus, and PSTA1-Mycobacterium tuberculosis).
In order to determine an optimal set of epitopes among the highest scoring predicted epitopes, the OptiTope tool was employed for populations susceptible to cutaneous leishmaniasis.
The epitope (127SLWSLLAGV) from antigen number 1, found to bind with the most prevalent allele HLA-A ⁎ 0201 (25% frequency in Southwest Asia), was predicted as most immunogenic for all the target populations.
Thus, our study reasserts the potential of genome-wide screening of pathogen antigens and epitopes, for identification of promising vaccine candidates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Satarudra Prakash& Roopendra, Kriti& Mishra, B. N.. 2015. Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1070412
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Satarudra Prakash…[et al.]. Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach. Journal of Tropical Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1070412
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Satarudra Prakash& Roopendra, Kriti& Mishra, B. N.. Genome-Wide Prediction of Vaccine Candidates for Leishmania major: An Integrated Approach. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1070412
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070412
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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