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Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice
المؤلفون المشاركون
Chachiyo, Sukanya
Somsak, Voravuth
Jaihan, Ubonwan
Nakinchat, Somrudee
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Malaria is a major public health problem in the world because it can cause of death in patients.
Malaria-associated renal injury is associated with 45% of mortality in adult patients hospitalized with severe form of the disease.
Therefore, new plant extracts to protect against renal injury induced by malaria infection are urgently needed.
In this study, we investigated the protective effect of aqueous crude extract of Azadirachta indica (neem) leaves on renal injury induced by Plasmodium berghei ANKA infection in mice.
ICR mice were injected intraperitoneally with 1 × 107 parasitized erythrocytes of PbANKA, and neem extracts (500, 1,000, and 2,000 mg/kg) were given orally for 4 consecutive days.
Plasma blood urea nitrogen (BUN) and creatinine levels were subsequently measured.
Malaria-induced renal injury was evidenced as marked increases of BUN and creatinine levels.
However, the oral administration of neem leaf extract to PbANKA infected mice for 4 days brought back BUN and creatinine levels to near normalcy, and the highest activity was observed at doses of 1,000 and 2,000 mg/kg.
Additionally, no toxic effects were found in normal mice treated with this extract.
Hence, neem leaf extract can be considered a potential candidate for protection against renal injury induced by malaria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Somsak, Voravuth& Chachiyo, Sukanya& Jaihan, Ubonwan& Nakinchat, Somrudee. 2015. Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1070420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Somsak, Voravuth…[et al.]. Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice. Journal of Tropical Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1070420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Somsak, Voravuth& Chachiyo, Sukanya& Jaihan, Ubonwan& Nakinchat, Somrudee. Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1070420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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