Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy
المؤلفون المشاركون
Ilias, Ioannis
Paraskevas, George P.
Kapaki, Elisabeth
Karagiorga, Vasiliki
Bourbouli, Mara
Pappa, Athina
Nikopoulou, Stamatina
Bougea, A.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Introduction.
Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis.
No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease.
Methods.
We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease.
Results.
The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P=0.007).
CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P=0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P=0.063).
Conclusions.
Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF.
Therefore, regarding Hashimoto’s encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ilias, Ioannis& Karagiorga, Vasiliki& Paraskevas, George P.& Bougea, A.& Bourbouli, Mara& Pappa, Athina…[et al.]. 2015. Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy. Journal of Thyroid Research،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1070430
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ilias, Ioannis…[et al.]. Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy. Journal of Thyroid Research No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1070430
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ilias, Ioannis& Karagiorga, Vasiliki& Paraskevas, George P.& Bougea, A.& Bourbouli, Mara& Pappa, Athina…[et al.]. Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy. Journal of Thyroid Research. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1070430
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070430
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر