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Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany
المؤلفون المشاركون
Fruehauf, Nils R.
Kutschmann, Marcus
Feindt, Johanna
Wirges, Ulrike
Rahmel, Axel
Schleicher, Christina
Schmidtmann, Irene
Kirste, Guenter
Fischer-Froehlich, Carl-Ludwig
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Scarcity of grafts for kidney transplantation (KTX) caused an increased consideration of deceased donors with substantial risk factors.
There is no agreement on which ones are detrimental for overall graft-survival.
Therefore, we investigated in a nationwide multicentre study the impact of donor and recipient related risks known before KTX on graft-survival based on the original data used for allocation and graft acceptance.
Methods.
A nationwide deidentified multicenter study-database was created of data concerning kidneys donated and transplanted in Germany between 2006 and 2008 as provided by the national organ procurement organization (Deutsche Stiftung Organtransplantation) and BQS Institute.
Multiple Cox regression (significance level 5%, hazard ratio [95% CI]) was conducted (n=4411, isolated KTX).
Results.
Risk factors associated with graft-survival were donor age (1.020 [1.013–1.027] per year), donor size (0.985 [0.977–0.993] per cm), donor’s creatinine at admission (1.002 [1.001–1.004] per µmol/L), donor treatment with catecholamine (0.757 [0.635–0.901]), and reduced graft-quality at procurement (1.549 [1.217–1.973]), as well as recipient age (1.012 [1.003–1.021] per year), actual panel reactive antibodies (1.007 [1.002–1.011] per percent), retransplantation (1.850 [1.484–2.306]), recipient’s cardiovascular comorbidity (1.436 [1.212–1.701]), and use of IL2-receptor antibodies for induction (0.741 [0.619–0.887]).
Conclusion.
Some donor characteristics persist to impact graft-survival (e.g., age) while the effect of others could be mitigated by elaborate donor-recipient match and care.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fischer-Froehlich, Carl-Ludwig& Kutschmann, Marcus& Feindt, Johanna& Schmidtmann, Irene& Kirste, Guenter& Fruehauf, Nils R.…[et al.]. 2015. Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany. Journal of Transplantation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1070434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fischer-Froehlich, Carl-Ludwig…[et al.]. Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany. Journal of Transplantation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1070434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fischer-Froehlich, Carl-Ludwig& Kutschmann, Marcus& Feindt, Johanna& Schmidtmann, Irene& Kirste, Guenter& Fruehauf, Nils R.…[et al.]. Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany. Journal of Transplantation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1070434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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