Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction
المؤلفون المشاركون
Wang, Jhi-Joung
Hung, Shih-Kai
Chen, Yeong-Chang
Wei, Tsui-Shan
Yeh, Ching-Hua
Sun, Ding-Ping
Hsing, Chung-Hsi
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Excessive production of cytokines by microglia may cause cognitive dysfunction and long-lasting behavioral changes.
Activating the peripheral innate immune system stimulates cytokine secretion in the central nervous system, which modulates cognitive function.
Histone deacetylases (HDACs) modulate cytokine synthesis and release.
Trichostatin A (TSA), an HDAC inhibitor, is documented to be anti-inflammatory and neuroprotective.
We investigated whether TSA reduces lipopolysaccharide- (LPS-) induced neuroinflammation and cognitive dysfunction.
ICR mice were first intraperitoneally (i.p.) injected with vehicle or TSA (0.3 mg/kg).
One hour later, they were injected (i.p.) with saline or Escherichia coli LPS (1 mg/kg).
We analyzed the food and water intake, body weight loss, and sucrose preference of the injected mice and then determined the microglia activation and inflammatory cytokine expression in the brains of LPS-treated mice and LPS-treated BV-2 microglial cells.
In the TSA-pretreated mice, microglial activation was lower, anhedonia did not occur, and LPS-induced cognitive dysfunction (anorexia, weight loss, and social withdrawal) was attenuated.
Moreover, mRNA expression of HDAC2, HDAC5, indoleamine 2,3-dioxygenase (IDO), TNF-α, MCP-1, and IL-1β in the brain of LPS-challenged mice and in the LPS-treated BV-2 microglial cells was lower.
TSA diminished LPS-induced inflammatory responses in the mouse brain and modulated the cytokine-associated changes in cognitive function, which might be specifically related to reducing HDAC2 and HDAC5 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsing, Chung-Hsi& Hung, Shih-Kai& Chen, Yeong-Chang& Wei, Tsui-Shan& Sun, Ding-Ping& Wang, Jhi-Joung…[et al.]. 2015. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsing, Chung-Hsi…[et al.]. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsing, Chung-Hsi& Hung, Shih-Kai& Chen, Yeong-Chang& Wei, Tsui-Shan& Sun, Ding-Ping& Wang, Jhi-Joung…[et al.]. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر